Endometrial dating histology
The physiopathology of the syndrome is investigated and discussed.
Ovulation could not be induced by using very high doses of gonadotropins.
Although the use of marker proteins provides additional information and may reflect endometrial function or receptivity, such markers cannot yet replace traditional methods of endometrial assessment.
Copyright (C) 2000 American Society for Reproductive Medicine. Patient(s): Fertile and infertile women undergoing endometrial biopsy.
The histologic features of what constitutes “normal” endometrium change with a woman’s age, through the premenarchal, reproductive, perimenopausal, and postmenopausal years.
During the reproductive years, the cyclical hormonal changes of the menstrual cycle provide a continuously changing morphologic phenotype that is “normal.” In biopsy specimens, the combination of these cyclical changes along with artifacts and limited sampling can make normal patterns difficult to interpret.
AB - Endometrial biopsy specimens (n = 62) were evaluated by five pathologists to assess the effect of interobserver variation on histologic dating of the endometrium.
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Of 1,090 patients who underwent sampling 6-10 days after detection of a urinary LH surge (corresponding to cycle days 20-24), multiple logistic regression analysis revealed that endometriosis was positively correlated and male factor infertility was negatively correlated with absent β3 integrin subunit expression.
Diagnosis and absent epithelial α4β1 expression were not related.